Disentangling a Bad Reputation: Changing Perceptions of Amyloids.
نویسندگان
چکیده
Historically, amyloids were perceived as toxic/irreversible protein aggregates associated with neurodegenerative disorders including Alzheimer's and Parkinson's diseases. Recent papers are challenging this perception by uncovering widespread cellular roles for physiological amyloidogenesis. These findings suggest that the amyloid-fold should be considered, alongside the native-fold and unfolded configurations, as a physiological and reversible protein organization.
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عنوان ژورنال:
- Trends in cell biology
دوره 27 7 شماره
صفحات -
تاریخ انتشار 2017